Scientists have just discovered a rare genetic mutation which raises hopes for fighting ageing and preventing age-related disorders ranging from heart disease to dementia. This had been discovered in an extended family of Old Order Amish living in the vicinity of Berne, Indiana.
The Amish community in rural Indiana said to have strong metabolic health, far lower rates of diabetes and lived around a decade longer than others in the community.
Scientists examined 177 members of the Old Order Amish in the town of Berne, Indiana and found that 43 of having inherited one normal and one mutated version of a gene called Serpine 1.
These Amish individuals have very low levels of PAI-1 also know as serpin E1 is a protein that comprises part of a “molecular fingerprint” related to ageing or senescence of cells
They said people with a version of the gene typically lived to 85 years old, a full 10 years more than those that did not carry the mutated form.
Dr. Douglas Vaughan, the lead author of the paper who has been studying PAI-1 for almost 30 years said “The findings astonished us because of the consistency of the anti-ageing benefits across multiple body systems,”
“For the first time we are seeing a molecular marker of aging (telomere length), a metabolic marker of aging (fasting insulin levels) and a cardiovascular marker of aging (blood pressure and blood vessel stiffness) all tracking in the same direction in that these individuals were generally protected from age-related changes,” Vaughan said.
He also said using this discovery they could protect humans from ageing problems.
“This is a rare genetic mutation that appears to protect against biological ageing in humans,”– he added.
Other tests also found a range of health benefits for those with the mutation, including increased metabolic health, lower levels of diabetes, and a longer lifespan.